This is a list made of characters who specialize or use a specific weapon when in combat, and if they have a signature weapon that belongs to them.
Aki Ishikawa
Weapon of choice: Katana
Signature weapon: Crimson Snow (former)
Alexander Vries
Weapon of choice: Bow
Signature weapon: (former) Black Caliber Bow, The Devourer
Amanda Kid
Weapon of choice: Steel Knuckles
Signature weapon: The Face Fractures
Ana
Weapon of choice: Scythe
Signature weapon: Dusk
Anon Gerse
Weapon of choice: Dual butcher knives
Anthony Tarpis
Weapon of choice: Dual chain scythe sickles
Signature weapon: Fury & Vengeance (former)
Archerios Cloudsmith
Weapon of choice: Sword
Signature weapon: King's Bane (former)
Arkore
Weapon of choice: Giant mace
Signature weapon: The Night Hammer
Asha Madrani
Weapon of choice: Double edged spears
Signature weapon: Sorrow Wind
Beatrice Angela
Weapon of choice: Dual battle axes
Dahlia Cortez
Weapon of choice: Cutlass
Signature weapon: Widow Maker
Damon Hollows
Weapon of choice: Dual tomahawks, butcher cleaver
Daniel Jones
Weapon of choice: Bladed shotgun
Signature weapon: The Monsoon
Dezmondus Alarai
Weapon of choice: Rapier
Signature weapon: The Alarai Sword
Elijah Kross
Weapon of choice: Dual revolvers
Ganath Deitus
Weapon of choice: Sword
Signature weapon: The Divinity Blade
Grimm Duskfall
Weapon of choice: Double edged scythe
Signature weapon: The Crimson Reaper
Hector Cortez
Weapon of choice: Giant scimitar
Signature weapon: The Butcher
James Price
Weapon of choice: Great axe
Signature weapon: King's Law
Jeremy DeGrandi
Weapon of choice: Dual custom pisols
Signature weapon: Kelly & Obelisk (former)
Jessica DeGrandi
Weapon of choice: Sniper rifle, dual custom pistols (rarely)
Signature weapon: The Black Shot (former), Kelly & Obelisk (rarely)
Kahn Madrani
Weapon of choice: Dual great knives
Katarina Saldar
Weapon of choice: Spiked whip
Signature weapon: The Rose Whip
Kong
Weapon of choice: Jungle bo staff
Leviathus
Weapon of choice: Odachi
Lyle Odrahn
Weapon of choice: Great sword
Marcus Vries
Weapon of choice: Crossbow
Mary Rose
Weapon of choice: Razors
Melissa Knightfall
Weapon of choice: Dual swords
Signature weapon: Moon & Star
Misty Snow
Weapon of choice: Dual cutlasses
Moira McKinley
Weapon of choice: Dual great axes
Moro Dahs
Weapon of choice: Halberd
Signature weapon: Overrun
Mumbles
Weapon of choice: Rifle
Mynna Avell
Weapon of choice: Dagger
Signature weapon: Wolf Fang
Nathan Jints
Weapon of choice: Mallet, dual chain scythe sickles
Signature weapon: The Squeaker, Fury & Vengeance
Nikolai
Weapon of choice: Giant iron mace
Pierce Verro
Weapon of choice: Zapper
Signature weapon: The Zeus Zapper
Raith Duskfall
Weapon of choice: Sword
Signature weapon: Dust
Ramo'ni Gu'ran
Weapon of choice: Gauntlets
Rebecca Fields
Weapon of choice: Dual sickle swords
Signature weapon: Lament & Anguish
Rick Tarpis
Weapon of choice: War claws
Ronin Blaze
Weapon of choice: Staff
Signature weapon: Shepherd of Fire
Sareesa
Weapon of choice: Dual kunai fans
Sean Carson
Weapon of choice: Odachi
Syllve
Weapon of choice: Staff
Tai Ishikawa
Weapon of choice: Katana
Signature weapon: Eien Surrasshu, Crimson Snow (rarely)
Tara Anders
Weapon of choice: Dual swords
Thanatos
Weapon of choice: Katana
Tyrannius Re
Weapon of choice: Double edged spear
Signature weapon: Ruin
Zaya Solari
Weapon of choice: Poison dagger (rarely)
Zhurong Razhari
Weapon of choice: Double edged scythe
Signature weapon: Dragonfire
Ziara Nightfang
Weapon of choice: Bow
Signature weapon: Nightsong